› 3mvs

X-ray diffraction
1.1Å resolution

Structure of the N-terminus of Cadherin 23

Released:
DOI: 10.2210/pdb3mvs/pdb
PDB entry 3mvs coloured by chain, front view.
PDB entry 3mvs coloured by chain, side view.
PDB entry 3mvs coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure of the N terminus of cadherin 23 reveals a new adhesion mechanism for a subset of cadherin superfamily members.
Elledge HM, Kazmierczak P, Clark P, Joseph JS, Kolatkar A, Kuhn P, Müller U
Proc Natl Acad Sci U S A 107 10708-12 (2010)
PMID: 20498078

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189374 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-23 Chain: A
Molecule details ›
Chain: A
Length: 210 amino acids
Theoretical weight: 23.27 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q99PF4 (Residues: 24-233; Coverage: 6%)
Gene name: Cdh23
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

2 bound ligands:
Ligand CA 6 x CA
Ligand EDO 22 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P21
Unit cell:
a: 38.375Å b: 64.208Å c: 47.859Å
α: 90° β: 110.89° γ: 90°
R-values:
R R work R free
0.164 0.163 0.188
Expression system: Escherichia coli BL21

Quick links

Citations

10 review citations

Cadherins in brain morphogenesis and wiring.
Hirano et al. (2012)
9 more

4 mentions without citation

Thinking outside the cell: how cadherins drive adhesion.
Brasch et al. (2012)
3 more