› 3n01

X-ray diffraction
1.3Å resolution

Crystal structure of an abridged form of the mature ectodomain of the Human Receptor-Type Protein Tyrosine Phosphatase ICA512/IA-2 at pH 8.5

Released:
DOI: 10.2210/pdb3n01/pdb
PDB entry 3n01 coloured by chain, front view.
PDB entry 3n01 coloured by chain, side view.
PDB entry 3n01 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Primo ME, Jakoncic J, Poskus E, Ermacora MR

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172595 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ICA512-transmembrane fragment Chains: A, B
Molecule details ›
Chains: A, B
Length: 89 amino acids
Theoretical weight: 9.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16849 (Residues: 470-558; Coverage: 9%)
Gene names: ICA3, ICA512, PTPRN
Sequence domains: Protein-tyrosine phosphatase receptor IA-2
Structure domains: Protein-tyrosine phosphatase receptor IA-2 ectodomain

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P212121
Unit cell:
a: 31.493Å b: 66.681Å c: 72.999Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.173 0.213
Expression system: Escherichia coli BL21(DE3)

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