› 3n2n

X-ray diffraction
1.8Å resolution

The Crystal Structure of Tumor Endothelial Marker 8 (TEM8) extracellular domain

Released:
DOI: 10.2210/pdb3n2n/pdb
PDB entry 3n2n coloured by chain, front view.
PDB entry 3n2n coloured by chain, side view.
PDB entry 3n2n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of tumor endothelial marker 8 (TEM8) extracellular domain and implications for its receptor function for recognizing anthrax toxin.
Fu S, Tong X, Cai C, Zhao Y, Wu Y, Li Y, Xu J, Zhang XC, Xu L, Chen W, Rao Z
PLoS One 5 e11203 (2010)
PMID: 20585457

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190650 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Anthrax toxin receptor 1 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 185 amino acids
Theoretical weight: 21.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H6X2 (Residues: 38-220; Coverage: 34%)
Gene names: ANTXR1, ATR, TEM8
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

2 bound ligands:
Ligand ACT 18 x ACT
Ligand MG 6 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P1
Unit cell:
a: 65.895Å b: 66.106Å c: 74.439Å
α: 63.68° β: 88.19° γ: 59.94°
R-values:
R R work R free
0.194 0.192 0.229
Expression system: Escherichia coli

Quick links

Citations

6 review citations

The dark sides of capillary morphogenesis gene 2.
Deuquet et al. (2012)
5 more

8 mentions without citation

Converging physiological roles of the anthrax toxin receptors.
Sergeeva et al. (2019)
7 more