› 3n4q

X-ray diffraction
3.2Å resolution

Human cytomegalovirus terminase nuclease domain, Mn soaked

Released:
DOI: 10.2210/pdb3n4q/pdb
PDB entry 3n4q coloured by chain, front view.
PDB entry 3n4q coloured by chain, side view.
PDB entry 3n4q coloured by chain, top view.
Source organism: Human herpesvirus 5 strain Towne
Primary publication:
Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain.
Nadal M, Mas PJ, Mas PJ, Blanco AG, Arnan C, Solà M, Hart DJ, Coll M
Proc Natl Acad Sci U S A 107 16078-83 (2010)
PMID: 20805464

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147805 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tripartite terminase subunit 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 279 amino acids
Theoretical weight: 31.82 KDa
Source organism: Human herpesvirus 5 strain Towne
Expression system: Escherichia coli
UniProt:
  • Canonical: P16732 (Residues: 418-674; Coverage: 38%)
Gene names: TRM3, UL89
Sequence domains: Probable DNA packing protein, C-terminus
Structure domains: Nucleotidyltransferase; domain 5

Ligands and Environments

2 bound ligands:
Ligand MN 8 x MN
Ligand MG 4 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 83.7Å b: 88.1Å c: 190.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.207 0.283
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Structure unifies the viral universe.
Abrescia et al. (2012)
14 more

5 mentions without citation

Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain.
Nadal et al. (2010)
4 more