› 3n7t

X-ray diffraction
2.1Å resolution

Crystal structure of a macrophage binding protein from Coccidioides immitis

Released:
DOI: 10.2210/pdb3n7t/pdb
PDB entry 3n7t coloured by chain, front view.
PDB entry 3n7t coloured by chain, side view.
PDB entry 3n7t coloured by chain, top view.
Source organism: Coccidioides immitis
Entry author: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Function and Biology Details

Reaction catalysed: 
(R)-lactate = methylglyoxal + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-190811 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
D-lactate dehydratase Chain: A
Molecule details ›
Chain: A
Length: 247 amino acids
Theoretical weight: 27.19 KDa
Source organism: Coccidioides immitis
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9HEU1 (Residues: 1-243; Coverage: 100%)
Gene name: MBP-1
Sequence domains: DJ-1/PfpI family
Structure domains: Rossmann fold

Ligands and Environments

3 bound ligands:
Ligand EDO 1 x EDO
Ligand CL 3 x CL
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P43212
Unit cell:
a: 89.41Å b: 89.41Å c: 107.01Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.161 0.159 0.192
Expression system: Escherichia coli

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