› 3n94

X-ray diffraction
1.8Å resolution

Crystal structure of human pituitary adenylate cyclase 1 Receptor-short N-terminal extracellular domain

Released:
DOI: 10.2210/pdb3n94/pdb
PDB entry 3n94 coloured by chain, front view.
PDB entry 3n94 coloured by chain, side view.
PDB entry 3n94 coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of the PAC1R extracellular domain unifies a consensus fold for hormone recognition by class B G-protein coupled receptors.
Kumar S, Pioszak A, Zhang C, Swaminathan K, Xu HE
PLoS One 6 e19682 (2011)
PMID: 21625560

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142539 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Maltose/maltodextrin-binding periplasmic protein; Pituitary adenylate cyclase-activating polypeptide type I receptor Chain: A
Molecule details ›
Chain: A
Length: 475 amino acids
Theoretical weight: 52.74 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: P0AEX9 (Residues: 25-392; Coverage: 99%)
  • Canonical: P41586 (Residues: 26-140; Coverage: 21%)
Gene names: ADCYAP1R1, JW3994, b4034, malE
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P212121
Unit cell:
a: 45.987Å b: 92.151Å c: 105.418Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.176 0.216
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR review 1.
Harmar et al. (2012)
10 more

13 mentions without citation

Structure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptors.
Pal et al. (2012)
12 more