› 3n9j

X-ray diffraction
1.85Å resolution

Structure of human Glutathione Transferase Pi class in complex with Ethacraplatin

Released:
DOI: 10.2210/pdb3n9j/pdb
PDB entry 3n9j coloured by chain, front view.
PDB entry 3n9j coloured by chain, side view.
PDB entry 3n9j coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Parker LJ, Parker MW

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140593 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase P Chains: A, B
Molecule details ›
Chains: A, B
Length: 210 amino acids
Theoretical weight: 23.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09211 (Residues: 1-210; Coverage: 100%)
Gene names: FAEES3, GST3, GSTP1
Sequence domains:
Structure domains:

Ligands and Environments

5 bound ligands:
Ligand PT 1 x PT
Ligand MES 2 x MES
Ligand EAA 2 x EAA
Ligand CA 3 x CA
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2
Unit cell:
a: 76.806Å b: 89.994Å c: 68.87Å
α: 90° β: 98.24° γ: 90°
R-values:
R R work R free
0.18 0.178 0.218
Expression system: Escherichia coli

Quick links

Citations

10 review citations

The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs.
Johnstone et al. (2016)
9 more