› 3nda

X-ray diffraction
1.8Å resolution

Crystal structure of serpin from tick Ixodes ricinus

Released:
DOI: 10.2210/pdb3nda/pdb
PDB entry 3nda coloured by chain, front view.
PDB entry 3nda coloured by chain, side view.
PDB entry 3nda coloured by chain, top view.
Source organism: Ixodes ricinus
Primary publication:
A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation.
Chmelar J, Oliveira CJ, Rezacova P, Francischetti IM, Kovarova Z, Pejler G, Kopacek P, Ribeiro JM, Mares M, Kopecky J, Kotsyfakis M
Blood 117 736-44 (2011)
PMID: 20940421

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170420 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Iripin-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 377 amino acids
Theoretical weight: 42.15 KDa
Source organism: Ixodes ricinus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06B74 (Residues: 22-397; Coverage: 100%)
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 1PE 1 x 1PE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X12
Spacegroup: P43
Unit cell:
a: 84.575Å b: 84.575Å c: 124.412Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.173 0.171 0.212
Expression system: Escherichia coli

Quick links

Citations

30 review citations

Tick salivary compounds: their role in modulation of host defences and pathogen transmission.
Kazimírová et al. (2013)
29 more

8 mentions without citation

Serpins in arthropod biology.
Meekins et al. (2017)
7 more