› 3nfs

X-ray diffraction
2.6Å resolution

Crystal structure the Fab fragment of therapeutic antibody daclizumab

Released:
DOI: 10.2210/pdb3nfs/pdb
PDB entry 3nfs coloured by chain, front view.
PDB entry 3nfs coloured by chain, side view.
PDB entry 3nfs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of immunosuppression by the therapeutic antibody daclizumab.
Yang H, Wang J, Du J, Zhong C, Zhang D, Guo H, Guo Y, Ding J
Cell Res 20 1361-71 (2010)
PMID: 20820193

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-234872 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Heavy chain of Fab fragment of daclizumab Chain: L
Molecule details ›
Chain: L
Length: 212 amino acids
Theoretical weight: 23.13 KDa
Source organism: Homo sapiens
Expression system: Not provided
Structure domains: Immunoglobulins
Light chain of Fab fragment of daclizumab Chain: H
Molecule details ›
Chain: H
Length: 216 amino acids
Theoretical weight: 23.03 KDa
Source organism: Homo sapiens
Expression system: Not provided
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P41212
Unit cell:
a: 67.866Å b: 67.866Å c: 205.607Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.225 0.275
Expression system: Not provided

Quick links

Citations

8 review citations

Impact of Immune-Modulatory Drugs on Regulatory T Cell.
Furukawa et al. (2016)
7 more

4 mentions without citation

Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses.
Wang et al. (2016)
3 more