› 3ni8

X-ray diffraction
2.5Å resolution

Crystal Structure of PFC0360w, an HSP90 activator from plasmodium falciparum

Released:
DOI: 10.2210/pdb3ni8/pdb
PDB entry 3ni8 coloured by chain, front view.
PDB entry 3ni8 coloured by chain, side view.
PDB entry 3ni8 coloured by chain, top view.
Source organism: Plasmodium falciparum
Entry authors: Wernimont AK, Hutchinson A, Sullivan H, MacKenzie F, Kozieradzki I, Cossar D, Bochkarev A, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Hui R, Pizzaro JC, Hills T, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179320 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Activator of Hsp90 ATPase homologue 1-like C-terminal domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 158 amino acids
Theoretical weight: 18.38 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q689C4 (Residues: 1-140; Coverage: 100%)
Gene name: PFC0360w
Sequence domains: Activator of Hsp90 ATPase homolog 1-like protein
Structure domains: Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4

Ligands and Environments

2 bound ligands:
Ligand IPA 2 x IPA
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P3121
Unit cell:
a: 96.658Å b: 96.658Å c: 44.288Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.226 0.224 0.261
Expression system: Escherichia coli

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