› 3nms

X-ray diffraction
4.1Å resolution

Staphylococcal Complement Inhibitor (SCIN) in complex with Human Complement C3c

Released:
DOI: 10.2210/pdb3nms/pdb
Model geometry
Fit model/data
PDB entry 3nms coloured by chain, front view.
PDB entry 3nms coloured by chain, side view.
PDB entry 3nms coloured by chain, top view.
Source organisms:
Primary publication:
Molecular basis for complement recognition and inhibition determined by crystallographic studies of the staphylococcal complement inhibitor (SCIN) bound to C3c and C3b.
Garcia BL, Ramyar KX, Tzekou A, Ricklin D, McWhorter WJ, Lambris JD, Geisbrecht BV
J Mol Biol 402 17-29 (2010)
PMID: 20654625

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133825 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Complement C3 beta chain Chain: A
Molecule details ›
Chain: A
Length: 645 amino acids
Theoretical weight: 71.39 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01024 (Residues: 23-667; Coverage: 39%)
Gene names: C3, CPAMD1
Sequence domains:
Complement C3c alpha' chain fragment 2 Chain: C
Molecule details ›
Chain: C
Length: 343 amino acids
Theoretical weight: 39.54 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01024 (Residues: 1321-1663; Coverage: 21%)
Gene names: C3, CPAMD1
Sequence domains:
Staphylococcal complement inhibitor Chain: M
Complement C3c alpha' chain fragment 1 Chain: B

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21212
Unit cell:
a: 214.067Å b: 68.434Å c: 114.928Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.273 0.271 0.289
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Complement System Part II: Role in Immunity.
Merle et al. (2015)
6 more

1 mention without citation

Molecular basis for complement recognition and inhibition determined by crystallographic studies of the staphylococcal complement inhibitor (SCIN) bound to C3c and C3b.
Garcia et al. (2010)