› 3np5

X-ray diffraction
1.8Å resolution

Crystal structure of an abridged form of the mature ectodomain of the human receptor-type protein tyrosine phosphatase ICA512/IA-2 AT pH 4.5

Released:
DOI: 10.2210/pdb3np5/pdb
PDB entry 3np5 coloured by chain, front view.
PDB entry 3np5 coloured by chain, side view.
PDB entry 3np5 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Primo ME, Jakoncic J, Poskus E, Ermacora MR

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172595 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ICA512-transmembrane fragment Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 89 amino acids
Theoretical weight: 9.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16849 (Residues: 470-558; Coverage: 9%)
Gene names: ICA3, ICA512, PTPRN
Sequence domains: Protein-tyrosine phosphatase receptor IA-2
Structure domains: Protein-tyrosine phosphatase receptor IA-2 ectodomain

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P41
Unit cell:
a: 44.662Å b: 44.662Å c: 168.665Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.165 0.161 0.239
Expression system: Escherichia coli BL21(DE3)

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