› 3nte

X-ray diffraction
1.95Å resolution

Crystal Structure of the Wild-type Full-Length HIV-1 Capsid Protein

Released:
DOI: 10.2210/pdb3nte/pdb
PDB entry 3nte coloured by chain, front view.
PDB entry 3nte coloured by chain, side view.
PDB entry 3nte coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Structure of the HIV-1 full-length capsid protein in a conformationally trapped unassembled state induced by small-molecule binding.
Du S, Betts L, Yang R, Shi H, Concel J, Ahn J, Aiken C, Zhang P, Yeh JI
J Mol Biol 406 371-86 (2011)
PMID: 21146540

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181219 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gag protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 221 amino acids
Theoretical weight: 24.63 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: Q77YG1 (Residues: 133-353; Coverage: 44%)
Gene name: gag
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand IOD 17 x IOD
Ligand I3M 2 x I3M
Ligand FE 23 x FE
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P21
Unit cell:
a: 47.91Å b: 86.532Å c: 55.589Å
α: 90° β: 99.73° γ: 90°
R-values:
R R work R free
0.206 0.204 0.253
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Roles of HIV-1 capsid in viral replication and immune evasion.
Le Sage et al. (2014)
6 more

22 mentions without citation

How HIV-1 Gag assembles in cells: Putting together pieces of the puzzle.
Lingappa et al. (2014)
21 more