› 3nve

X-ray diffraction
1.7Å resolution

MMHFGN segment 138-143 from Syrian Hamster prion

Released:
DOI: 10.2210/pdb3nve/pdb
PDB entry 3nve coloured by chain, front view.
PDB entry 3nve coloured by chain, side view.
PDB entry 3nve coloured by chain, top view.
Source organism: Mesocricetus auratus
Primary publication:
Atomic structures suggest determinants of transmission barriers in mammalian prion disease.
Apostol MI, Wiltzius JJ, Sawaya MR, Cascio D, Eisenberg D
Biochemistry 50 2456-63 (2011)
PMID: 21323366

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137560 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Major prion protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 6 amino acids
Theoretical weight: 737 Da
Source organism: Mesocricetus auratus
Expression system: Not provided
UniProt:
  • Canonical: P04273 (Residues: 138-143; Coverage: 3%)
Gene names: PRNP, PRP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-D
Spacegroup: P21
Unit cell:
a: 9.513Å b: 11.784Å c: 36.541Å
α: 90° β: 93.04° γ: 90°
R-values:
R R work R free
0.206 0.196 0.269
Expression system: Not provided

Quick links

Citations

12 review citations

The activities of amyloids from a structural perspective.
Riek et al. (2016)
11 more

6 mentions without citation

Atomic structures suggest determinants of transmission barriers in mammalian prion disease.
Apostol et al. (2011)
5 more