› 3nvf

X-ray diffraction
1.8Å resolution

IIHFGS segment 138-143 from human prion

Released:
DOI: 10.2210/pdb3nvf/pdb
PDB entry 3nvf coloured by chain, front view.
PDB entry 3nvf coloured by chain, side view.
PDB entry 3nvf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Atomic structures suggest determinants of transmission barriers in mammalian prion disease.
Apostol MI, Wiltzius JJ, Sawaya MR, Cascio D, Eisenberg D
Biochemistry 50 2456-63 (2011)
PMID: 21323366

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137462 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Major prion protein Chain: A
Molecule details ›
Chain: A
Length: 6 amino acids
Theoretical weight: 674 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04156 (Residues: 138-143; Coverage: 3%)
Gene names: ALTPRP, PRIP, PRNP, PRP

Ligands and Environments

1 bound ligand:
Ligand MPD 1 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID13
Spacegroup: P21212
Unit cell:
a: 27.546Å b: 31.017Å c: 4.804Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.212 0.226
Expression system: Not provided

Quick links

Citations

12 review citations

The activities of amyloids from a structural perspective.
Riek et al. (2016)
11 more

4 mentions without citation

Atomic structures suggest determinants of transmission barriers in mammalian prion disease.
Apostol et al. (2011)
3 more