› 3nvh

X-ray diffraction
1.61Å resolution

MIHFGND segment 137-143 from mouse prion

Released:
DOI: 10.2210/pdb3nvh/pdb
PDB entry 3nvh coloured by chain, front view.
PDB entry 3nvh coloured by chain, side view.
PDB entry 3nvh coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Atomic structures suggest determinants of transmission barriers in mammalian prion disease.
Apostol MI, Wiltzius JJ, Sawaya MR, Cascio D, Eisenberg D
Biochemistry 50 2456-63 (2011)
PMID: 21323366

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138275 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Major prion protein Chain: A
Molecule details ›
Chain: A
Length: 7 amino acids
Theoretical weight: 834 Da
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P04925 (Residues: 137-143; Coverage: 3%)
Gene names: Prn-p, Prnp, Prp

Ligands and Environments

1 bound ligand:
Ligand TFA 1 x TFA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID13
Spacegroup: P212121
Unit cell:
a: 30.28Å b: 4.873Å c: 31.107Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.169 0.166 0.197
Expression system: Not provided

Quick links

Citations

12 review citations

The activities of amyloids from a structural perspective.
Riek et al. (2016)
11 more

3 mentions without citation

Atomic structures suggest determinants of transmission barriers in mammalian prion disease.
Apostol et al. (2011)
2 more