› 3nwf

X-ray diffraction
3Å resolution

Glycoprotein B from Herpes simplex virus type 1, low-pH

Released:
DOI: 10.2210/pdb3nwf/pdb
PDB entry 3nwf coloured by chain, front view.
PDB entry 3nwf coloured by chain, side view.
PDB entry 3nwf coloured by chain, top view.
Source organism: Human alphaherpesvirus 1 strain KOS
Primary publication:
Structural basis of local, pH-dependent conformational changes in glycoprotein B from herpes simplex virus type 1.
Stampfer SD, Lou H, Cohen GH, Eisenberg RJ, Heldwein EE
J Virol 84 12924-33 (2010)
PMID: 20943984

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139046 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Envelope glycoprotein B Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 703 amino acids
Theoretical weight: 78.87 KDa
Source organism: Human alphaherpesvirus 1 strain KOS
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P06437 (Residues: 30-730; Coverage: 80%)
Gene names: UL27, gB
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand NAG 8 x NAG
Ligand MRY 2 x MRY
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P3
Unit cell:
a: 117.802Å b: 117.802Å c: 318.324Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.199 0.197 0.249
Expression system: Spodoptera frugiperda

Quick links

Citations

12 review citations

Silver nanoparticles as potential antiviral agents.
Galdiero et al. (2011)
11 more

8 mentions without citation

Peptide entry inhibitors of enveloped viruses: the importance of interfacial hydrophobicity.
Badani et al. (2014)
7 more