› 3nx5

X-ray diffraction
2.31Å resolution

The crystal structure of Sanguinarine bound to DNA d(CGTACG)

Released:
DOI: 10.2210/pdb3nx5/pdb
PDB entry 3nx5 coloured by chain, front view.
PDB entry 3nx5 coloured by chain, side view.
PDB entry 3nx5 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG).
Ferraroni M, Bazzicalupi C, Bilia AR, Gratteri P
Chem Commun (Camb) 47 4917-9 (2011)
PMID: 21431128

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-116627 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*CP*GP*TP*AP*CP*G)-3' Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand SAU 1 x SAU
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P3221
Unit cell:
a: 29.992Å b: 29.992Å c: 119.069Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.255 0.252 0.283
Expression system: Not provided

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Citations

1 review citation

The Phytochemistry of Cherokee Aromatic Medicinal Plants.
Setzer WN. (2018)
20 other articles