› 3nxb

X-ray diffraction
1.83Å resolution

Crystal Structure of the Bromodomain of human CECR2

Released:
DOI: 10.2210/pdb3nxb/pdb
PDB entry 3nxb coloured by chain, front view.
PDB entry 3nxb coloured by chain, side view.
PDB entry 3nxb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Histone recognition and large-scale structural analysis of the human bromodomain family.
Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Müller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S
Cell 149 214-31 (2012)
PMID: 22464331

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189786 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chromatin remodeling regulator CECR2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 116 amino acids
Theoretical weight: 13.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9BXF3 (Residues: 424-538; Coverage: 8%)
Gene names: CECR2, KIAA1740
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: C2
Unit cell:
a: 127.16Å b: 45.51Å c: 45.59Å
α: 90° β: 105.67° γ: 90°
R-values:
R R work R free
0.178 0.176 0.214
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

245 review citations

Modification of enhancer chromatin: what, how, and why?
Calo et al. (2013)
244 more

7 mentions without citation

Predictions of Ligand Selectivity from Absolute Binding Free Energy Calculations.
Aldeghi et al. (2017)
6 more