› 3nz8

X-ray diffraction
2.7Å resolution

Crystal structure of the HIV-2 neutralizing Fab fragment 7C8

Released:
DOI: 10.2210/pdb3nz8/pdb
PDB entry 3nz8 coloured by chain, front view.
PDB entry 3nz8 coloured by chain, side view.
PDB entry 3nz8 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure of the HIV-2 neutralizing Fab fragment 7C8 with high specificity to the V3 region of gp125.
Uchtenhagen H, Friemann R, Raszewski G, Spetz AL, Nilsson L, Achour A
PLoS One 6 e18767 (2011)
PMID: 21541316

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213339 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mouse anti V3 antibody 7C8 Fab, heavy chain Chains: A, H
Molecule details ›
Chains: A, H
Length: 221 amino acids
Theoretical weight: 23.75 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins
Mouse anti V3 antibody 7C8 Fab, light chain Chains: B, L
Molecule details ›
Chains: B, L
Length: 218 amino acids
Theoretical weight: 24.13 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I711
Spacegroup: P3221
Unit cell:
a: 100.071Å b: 100.071Å c: 196.763Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.229 0.226 0.273
Expression system: Mus musculus

Quick links

Citations

1 review citation

Antiretroviral therapy and drug resistance in human immunodeficiency virus type 2 infection.
Menéndez-Arias et al. (2014)
3 other articles

4 mentions without citation

Advances in Antibody Design.
Tiller et al. (2015)
3 more