› 3o3x

X-ray diffraction
1.45Å resolution

Crystal structure of gp41-5, a single-chain 5-helix-bundle based on HIV gp41

Released:
DOI: 10.2210/pdb3o3x/pdb
Model geometry
Fit model/data
PDB entry 3o3x coloured by chain, front view.
PDB entry 3o3x coloured by chain, side view.
PDB entry 3o3x coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Broad distribution of energetically important contacts across an extended protein interface.
Johnson LM, Horne WS, Gellman SH
J Am Chem Soc 133 10038-41 (2011)
PMID: 21644542

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-163834 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
gp41-5 Chain: A
Molecule details ›
Chain: A
Length: 198 amino acids
Theoretical weight: 22.25 KDa
Source organism: synthetic construct
Expression system: Escherichia coli

Ligands and Environments

2 bound ligands:
Ligand MPD 1 x MPD
Ligand IPA 1 x IPA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P212121
Unit cell:
a: 54.459Å b: 57.936Å c: 61.689Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.152 0.15 0.181
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Protease-resistant peptide design-empowering nature's fragile warriors against HIV.
Weinstock et al. (2012)
2 more

3 mentions without citation

α-Helix mimicry with α/β-peptides.
Johnson et al. (2013)
2 more