› 3o43

X-ray diffraction
2.8Å resolution

Complex of an alpha/beta-peptide based on the gp41 CHR domain bound to gp41-5

Released:
DOI: 10.2210/pdb3o43/pdb
PDB entry 3o43 coloured by chain, front view.
PDB entry 3o43 coloured by chain, side view.
PDB entry 3o43 coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Broad distribution of energetically important contacts across an extended protein interface.
Johnson LM, Horne WS, Gellman SH
J Am Chem Soc 133 10038-41 (2011)
PMID: 21644542

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-163839 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
gp41-5 Chain: A
Molecule details ›
Chain: A
Length: 198 amino acids
Theoretical weight: 22.25 KDa
Source organism: synthetic construct
Expression system: Escherichia coli
alpha/beta-peptide derived from gp41 CHR domain sequence Chain: B
Molecule details ›
Chain: B
Length: 40 amino acids
Theoretical weight: 4.53 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand GOL 4 x GOL
2 modified residues:
Ligand B3T 1 x B3T
Ligand B3E 3 x B3E

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P212121
Unit cell:
a: 47.808Å b: 57.621Å c: 101.84Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.193 0.285
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

3 review citations

Protease-resistant peptide design-empowering nature's fragile warriors against HIV.
Weinstock et al. (2012)
2 more

5 mentions without citation

Folding and function in α/β-peptides: targets and therapeutic applications.
Werner et al. (2015)
4 more