› 3o70

X-ray diffraction
1.85Å resolution

PHD-type zinc finger of human PHD finger protein 13

Released:
DOI: 10.2210/pdb3o70/pdb
PDB entry 3o70 coloured by chain, front view.
PDB entry 3o70 coloured by chain, side view.
PDB entry 3o70 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3.
Chung HR, Xu C, Fuchs A, Mund A, Lange M, Staege H, Schubert T, Bian C, Dunkel I, Eberharter A, Regnard C, Klinker H, Meierhofer D, Cozzuto L, Winterpacht A, Di Croce L, Min J, Will H, Kinkley S
Elife 5 (2016)
PMID: 27223324

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-183267 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PHD finger protein 13 Chain: A
Molecule details ›
Chain: A
Length: 68 amino acids
Theoretical weight: 8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q86YI8 (Residues: 232-281; Coverage: 17%)
Gene name: PHF13
Sequence domains: PhD finger domain
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)

Ligands and Environments

2 bound ligands:
Ligand GOL 2 x GOL
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P43212
Unit cell:
a: 58.315Å b: 58.315Å c: 73.231Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.184 0.188
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Is H3K4me3 instructive for transcription activation?
Howe et al. (2017)
4 more

4 mentions without citation

Solution NMR structure and histone binding of the PHD domain of human MLL5.
Lemak et al. (2013)
3 more