› 3oah

X-ray diffraction
3Å resolution

Structural Characterization of the Dual Glycan Binding Adeno-Associated Virus Serotype 6

Released:
DOI: 10.2210/pdb3oah/pdb
PDB entry 3oah coloured by chain, front view.
PDB entry 3oah coloured by chain, side view.
PDB entry 3oah coloured by chain, top view.
Source organism: Adeno-associated virus - 6
Primary publication:
Structural characterization of the dual glycan binding adeno-associated virus serotype 6.
Ng R, Govindasamy L, Gurda BL, McKenna R, Kozyreva OG, Samulski RJ, Parent KN, Baker TS, Agbandje-McKenna M
J Virol 84 12945-57 (2010)
PMID: 20861247

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 60-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129573 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein VP1 Chain: A
Molecule details ›
Chain: A
Length: 534 amino acids
Theoretical weight: 59.66 KDa
Source organism: Adeno-associated virus - 6
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O56137 (Residues: 203-736; Coverage: 73%)
Sequence domains: Parvovirus coat protein VP2
Structure domains: Parvovirus coat protein VP1/VP2

Ligands and Environments

2 bound ligands:
Ligand CYT 1 x CYT
Ligand OAH 1 x OAH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: R32
Unit cell:
a: 263Å b: 263Å c: 609Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.275 0.275 0.288
Expression system: Spodoptera frugiperda

Quick links

Citations

27 review citations

Adeno-Associated Virus (AAV) as a Vector for Gene Therapy.
Naso et al. (2017)
26 more

13 mentions without citation

Nucleic acid packaging in viruses.
Speir et al. (2012)
12 more