› 3oai

X-ray diffraction
2.1Å resolution

Crystal structure of the extra-cellular domain of human myelin protein zero

Released:
DOI: 10.2210/pdb3oai/pdb
PDB entry 3oai coloured by chain, front view.
PDB entry 3oai coloured by chain, side view.
PDB entry 3oai coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of the extracellular domain of human myelin protein zero.
Liu Z, Wang Y, Yedidi RS, Brunzelle JS, Kovari IA, Sohi J, Kamholz J, Kovari LC
Proteins 80 307-13 (2012)
PMID: 21971831

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142524 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Maltose/maltodextrin-binding periplasmic protein; Myelin protein P0 Chains: A, B
Molecule details ›
Chains: A, B
Length: 507 amino acids
Theoretical weight: 56.37 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: P0AEX9 (Residues: 27-392; Coverage: 99%)
  • Canonical: P25189 (Residues: 30-150; Coverage: 55%)
Gene names: JW3994, MPZ, b4034, malE
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P21
Unit cell:
a: 61.9Å b: 54.886Å c: 146.069Å
α: 90° β: 98.54° γ: 90°
R-values:
R R work R free
0.186 0.183 0.252
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Myelin-specific proteins: a structurally diverse group of membrane-interacting molecules.
Han et al. (2013)
1 more

6 mentions without citation

Crystal structures of MBP fusion proteins.
Waugh DS. (2016)
5 more