› 3on9

X-ray diffraction
1.57Å resolution

The SECRET domain from Ectromelia virus

Released:
DOI: 10.2210/pdb3on9/pdb
PDB entry 3on9 coloured by chain, front view.
PDB entry 3on9 coloured by chain, side view.
PDB entry 3on9 coloured by chain, top view.
Source organism: Ectromelia virus
Primary publication:
Structural basis of chemokine sequestration by CrmD, a poxvirus-encoded tumor necrosis factor receptor.
Xue X, Lu Q, Wei H, Wang D, Chen D, He G, Huang L, Wang H, Wang X
PLoS Pathog 7 e1002162 (2011)
PMID: 21829356

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182015 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TNFR-Cys domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 163 amino acids
Theoretical weight: 18.01 KDa
Source organism: Ectromelia virus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7TDW8 (Residues: 162-320; Coverage: 50%)
Gene name: crmD
Sequence domains: Tumour necrosis factor receptor, SECRET domain
Structure domains: Viral Chemokine Inhibitor; Chain A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: C2221
Unit cell:
a: 72.416Å b: 73.438Å c: 112.412Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.165 0.164 0.198
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity.
Smith et al. (2013)
10 more

6 mentions without citation

Subversion of cytokine networks by virally encoded decoy receptors.
Epperson et al. (2012)
5 more