› 3org

X-ray diffraction
3.5Å resolution

Crystal Structure of a eukaryotic CLC transporter

Released:
DOI: 10.2210/pdb3org/pdb
PDB entry 3org coloured by chain, front view.
PDB entry 3org coloured by chain, side view.
PDB entry 3org coloured by chain, top view.
Source organism: Cyanidioschyzon merolae
Primary publication:
Structure of a eukaryotic CLC transporter defines an intermediate state in the transport cycle.
Feng L, Campbell EB, Hsiung Y, MacKinnon R
Science 330 635-41 (2010)
PMID: 20929736

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-163870 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CmCLC Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 632 amino acids
Theoretical weight: 69.15 KDa
Source organism: Cyanidioschyzon merolae
Expression system: Trichoplusia ni
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CL 8 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: C2
Unit cell:
a: 229.629Å b: 178.27Å c: 145.135Å
α: 90° β: 129.21° γ: 90°
R-values:
R R work R free
0.261 0.259 0.284
Expression system: Trichoplusia ni

Quick links

Citations

37 review citations

Lysosomal acidification mechanisms.
Mindell JA. (2012)
36 more

37 mentions without citation

CLC channel function and dysfunction in health and disease.
Stölting et al. (2014)
36 more