› 3osm

X-ray diffraction
1.7Å resolution

Structure of the Kinase Associated Domain-1 (KA1) from Kcc4p

Released:
DOI: 10.2210/pdb3osm/pdb
PDB entry 3osm coloured by chain, front view.
PDB entry 3osm coloured by chain, side view.
PDB entry 3osm coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids.
Moravcevic K, Mendrola JM, Schmitz KR, Wang YH, Slochower D, Janmey PA, Lemmon MA
Cell 143 966-77 (2010)
PMID: 21145462

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150457 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Probable serine/threonine-protein kinase KCC4 Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 14.74 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: P25389 (Residues: 917-1037; Coverage: 12%)
Gene names: KCC4, YCL024W, YCL24W
Sequence domains: Fungal kinase associated-1 domain
Structure domains: Fungal kinase associated-1 domain

Ligands and Environments

2 bound ligands:
Ligand SRT 1 x SRT
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F2
Spacegroup: P1
Unit cell:
a: 26.24Å b: 33.228Å c: 38.145Å
α: 104.15° β: 90.7° γ: 107°
R-values:
R R work R free
0.188 0.187 0.197
Expression system: Escherichia coli

Quick links

Citations

36 review citations

Phosphoinositides: tiny lipids with giant impact on cell regulation.
Balla T. (2013)
35 more

5 mentions without citation

Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids.
Moravcevic et al. (2010)
4 more