› 3osy

X-ray diffraction
2.99Å resolution

Human enterovirus 71 3C protease

Released:
DOI: 10.2210/pdb3osy/pdb
PDB entry 3osy coloured by chain, front view.
PDB entry 3osy coloured by chain, side view.
PDB entry 3osy coloured by chain, top view.
Source organism: Enterovirus A71
Primary publication:
Crystal structure of human enterovirus 71 3C protease.
Cui S, Wang J, Fan T, Qin B, Guo L, Lei X, Wang J, Wang M, Jin Q
J Mol Biol 408 449-61 (2011)
PMID: 21396941

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-110790 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3C protease Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 204 amino acids
Theoretical weight: 22.49 KDa
Source organism: Enterovirus A71
Expression system: Escherichia coli
UniProt:
  • Canonical: B8YLV9 (Residues: 1-183; Coverage: 100%)
Sequence domains: 3C cysteine protease (picornain 3C)
Structure domains: Trypsin-like serine proteases

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P21
Unit cell:
a: 54.288Å b: 75.121Å c: 125.153Å
α: 90° β: 90.11° γ: 90°
R-values:
R R work R free
0.209 0.206 0.259
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Antiviral drug discovery for the treatment of enterovirus 71 infections.
Shang et al. (2013)
8 more

14 mentions without citation

Enteroviruses and coronaviruses: similarities and therapeutic targets.
Marjomäki et al. (2021)
13 more