› 3oza

X-ray diffraction
3Å resolution

Crystal Structure of Plasmodium falciparum 3-Phosphoglycerate Kinase

Released:
DOI: 10.2210/pdb3oza/pdb
PDB entry 3oza coloured by chain, front view.
PDB entry 3oza coloured by chain, side view.
PDB entry 3oza coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Primary publication:
Crystal structure of Plasmodium falciparum phosphoglycerate kinase: evidence for anion binding in the basic patch.
Smith CD, Chattopadhyay D, Pal B
Biochem Biophys Res Commun 412 203-6 (2011)
PMID: 21798238

Function and Biology Details

Reaction catalysed: 
ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150987 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphoglycerate kinase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 424 amino acids
Theoretical weight: 46.97 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
UniProt:
  • Canonical: P27362 (Residues: 2-416; Coverage: 100%)
Gene names: PFI1105w, PGK
Sequence domains: Phosphoglycerate kinase
Structure domains: Phosphoglycerate kinase, N-terminal domain

Ligands and Environments

2 bound ligands:
Ligand SO4 4 x SO4
Ligand GOL 2 x GOL
1 modified residue:
Ligand MSE 27 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: I222
Unit cell:
a: 119.03Å b: 147.61Å c: 206.49Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.2 0.271
Expression system: Escherichia coli

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Citations

4 review citations

From crystal to compound: structure-based antimalarial drug discovery.
Drinkwater et al. (2014)
3 more

2 mentions without citation

The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking Investigations.
Ogungbe et al. (2016)
1 more