› 3oze

X-ray diffraction
2Å resolution

Crystal Structure of human 5'-deoxy-5'-methyladenosine phosphorylase

Released:
DOI: 10.2210/pdb3oze/pdb
Model geometry
Fit model/data
PDB entry 3oze coloured by chain, front view.
PDB entry 3oze coloured by chain, side view.
PDB entry 3oze coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ho M, Guan R, Almo SC, Schramm VL

Function and Biology Details

Reaction catalysed: 
S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171545 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
S-methyl-5'-thioadenosine phosphorylase Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 283 amino acids
Theoretical weight: 31.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13126 (Residues: 1-283; Coverage: 100%)
Gene names: MSAP, MTAP
Sequence domains: Phosphorylase superfamily
Structure domains: Nucleoside phosphorylase domain

Ligands and Environments

1 bound ligand:
Ligand PO4 6 x PO4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21
Unit cell:
a: 79.517Å b: 81.81Å c: 130.282Å
α: 90° β: 91° γ: 90°
R-values:
R R work R free
0.218 0.216 0.262
Expression system: Escherichia coli BL21(DE3)

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