› 3p0u

X-ray diffraction
3Å resolution

Crystal Structure of the ligand binding domain of human testicular receptor 4

Released:
DOI: 10.2210/pdb3p0u/pdb
PDB entry 3p0u coloured by chain, front view.
PDB entry 3p0u coloured by chain, side view.
PDB entry 3p0u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The orphan nuclear receptor TR4 is a vitamin A-activated nuclear receptor.
Zhou XE, Suino-Powell KM, Xu Y, Chan CW, Tanabe O, Kruse SW, Reynolds R, Engel JD, Xu HE
J Biol Chem 286 2877-85 (2011)
PMID: 21068381

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155862 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear receptor subfamily 2 group C member 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 249 amino acids
Theoretical weight: 28.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49116 (Residues: 348-596; Coverage: 42%)
Gene names: NR2C2, TAK1, TR4
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: F222
Unit cell:
a: 129.479Å b: 140.963Å c: 184.863Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.26 0.258 0.287
Expression system: Escherichia coli

Quick links

Citations

19 review citations

Vitamin A and retinoid signaling: genomic and nongenomic effects.
Al Tanoury et al. (2013)
18 more

8 mentions without citation

Strategies for developing pregnane X receptor antagonists: Implications from metabolism to cancer.
Chai et al. (2020)
7 more