› 3pc6

X-ray diffraction
1.9Å resolution

X-ray crystal structure of the second XRCC1 BRCT domain.

Released:
DOI: 10.2210/pdb3pc6/pdb
PDB entry 3pc6 coloured by chain, front view.
PDB entry 3pc6 coloured by chain, side view.
PDB entry 3pc6 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The structural basis for partitioning of the XRCC1/DNA ligase III-α BRCT-mediated dimer complexes.
Cuneo MJ, Gabel SA, Krahn JM, Ricker MA, London RE
Nucleic Acids Res 39 7816-27 (2011)
PMID: 21652643

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178790 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA repair protein XRCC1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 104 amino acids
Theoretical weight: 12.59 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q60596 (Residues: 534-631; Coverage: 16%)
Gene names: Xrcc-1, Xrcc1
Sequence domains: BRCT domain, a BRCA1 C-terminus domain
Structure domains: BRCT domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 44.23Å b: 56.85Å c: 100.38Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.18 0.227
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

11 review citations

Base excision repair of oxidative DNA damage: from mechanism to disease.
Whitaker et al. (2017)
10 more

7 mentions without citation

Coordination of DNA single strand break repair.
Abbotts et al. (2017)
6 more