› 3pfn

X-ray diffraction
2.7Å resolution

Crystal Structure of human NAD kinase

Released:
DOI: 10.2210/pdb3pfn/pdb
PDB entry 3pfn coloured by chain, front view.
PDB entry 3pfn coloured by chain, side view.
PDB entry 3pfn coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Wang H, Tempel W, Wernimont AK, Tong Y, Guan X, Shen Y, Li Y, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + NAD(+) = ADP + NADP(+)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131946 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NAD kinase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 365 amino acids
Theoretical weight: 40.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O95544 (Residues: 68-426; Coverage: 81%)
Gene name: NADK
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand UNX 62 x UNX
1 modified residue:
Ligand MSE 44 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 66.095Å b: 133.587Å c: 162.668Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.209 0.236
Expression system: Escherichia coli BL21(DE3)

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