› 3ph7

X-ray diffraction
2.5Å resolution

Crystal structure of Plasmodium vivax putative polyprenyl pyrophosphate synthase in complex with geranylgeranyl diphosphate

Released:
DOI: 10.2210/pdb3ph7/pdb
PDB entry 3ph7 coloured by chain, front view.
PDB entry 3ph7 coloured by chain, side view.
PDB entry 3ph7 coloured by chain, top view.
Source organism: Plasmodium vivax
Primary publication:
Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites.
Artz JD, Wernimont AK, Dunford JE, Schapira M, Dong A, Zhao Y, Lew J, Russell RG, Ebetino FH, Oppermann U, Hui R
J Biol Chem 286 3315-22 (2011)
PMID: 21084289

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107670 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Farnesyl pyrophosphate synthase, putative Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 396 amino acids
Theoretical weight: 46.22 KDa
Source organism: Plasmodium vivax
Expression system: Escherichia coli
UniProt:
  • Canonical: A5K4U6 (Residues: 1-375; Coverage: 100%)
Gene name: PVX_092040
Sequence domains: Polyprenyl synthetase
Structure domains: Farnesyl Diphosphate Synthase

Ligands and Environments

1 bound ligand:
Ligand GRG 4 x GRG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ DW
Spacegroup: P212121
Unit cell:
a: 107.095Å b: 108.985Å c: 141.354Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.235 0.273
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Bisphosphonates: the first 40 years.
Russell RG. (2011)
8 more

4 mentions without citation

Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites.
Artz et al. (2011)
3 more