› 3phh

X-ray diffraction
1.42Å resolution

Shikimate 5-Dehydrogenase (aroE) from Helicobacter pylori in complex with Shikimate

Released:
DOI: 10.2210/pdb3phh/pdb
PDB entry 3phh coloured by chain, front view.
PDB entry 3phh coloured by chain, side view.
PDB entry 3phh coloured by chain, top view.
Source organism: Helicobacter pylori 26695
Entry authors: Cheng WC, Lin SC, Wang WC

Function and Biology Details

Reaction catalysed: 
Shikimate + NADP(+) = 3-dehydroshikimate + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157396 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Shikimate dehydrogenase (NADP(+)) Chain: A
Molecule details ›
Chain: A
Length: 269 amino acids
Theoretical weight: 30.14 KDa
Source organism: Helicobacter pylori 26695
Expression system: Escherichia coli
UniProt:
  • Canonical: P56119 (Residues: 1-263; Coverage: 100%)
Gene names: HP_1249, aroE
Sequence domains: Shikimate dehydrogenase substrate binding domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SKM 1 x SKM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P212121
Unit cell:
a: 46.37Å b: 62.798Å c: 84.38Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.197 0.227
Expression system: Escherichia coli

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