3pk1

X-ray diffraction
2.49Å resolution

Crystal structure of Mcl-1 in complex with the BaxBH3 domain

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-170509 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Induced myeloid leukemia cell differentiation protein Mcl-1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 189 amino acids
Theoretical weight: 21.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07820 (Residues: 174-326; Coverage: 44%)
Gene names: BCL2L3, MCL1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like
Apoptosis regulator BAX Chains: B, D
Molecule details ›
Chains: B, D
Length: 34 amino acids
Theoretical weight: 3.84 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q07812 (Residues: 48-81; Coverage: 18%)
Gene names: BAX, BCL2L4

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: C2
Unit cell:
a: 97.923Å b: 81.469Å c: 57.927Å
α: 90° β: 124.23° γ: 90°
R-values:
R R work R free
0.214 0.212 0.245
Expression systems:
  • Escherichia coli
  • Not provided