› 3plc

X-ray diffraction
2.41Å resolution

Crystal structure of Beta-Cardiotoxin, a novel three-finger cardiotoxin from the venom of Ophiophagus hannah

Released:
DOI: 10.2210/pdb3plc/pdb
PDB entry 3plc coloured by chain, front view.
PDB entry 3plc coloured by chain, side view.
PDB entry 3plc coloured by chain, top view.
Source organism: Ophiophagus hannah
Primary publication:
Identification of a α-helical molten globule intermediate and structural characterization of β-cardiotoxin, an all β-sheet protein isolated from the venom of Ophiophagus hannah (king cobra).
Roy A, Qingxiang S, Alex C, Rajagopalan N, Jobichen C, Sivaraman J, Kini RM
Protein Sci 28 952-963 (2019)
PMID: 30891862

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179376 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-cardiotoxin CTX27 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 63 amino acids
Theoretical weight: 7.03 KDa
Source organism: Ophiophagus hannah
UniProt:
  • Canonical: Q69CK0 (Residues: 22-84; Coverage: 100%)
Sequence domains: u-PAR/Ly-6 domain
Structure domains: CD59

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: P31
Unit cell:
a: 58.949Å b: 58.949Å c: 53.026Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.237 0.234 0.267

Quick links

Citations

2 citation in other articles

Suppression of cardiomyocyte functions by β-CTX isolated from the Thai king cobra (Ophiophagus hannah) venom via an alternative method.
Lertwanakarn et al. (2020)
1 more

5 mentions without citation

Evolution and Medical Significance of LU Domain-Containing Proteins.
Leth et al. (2019)
4 more