› 3ppe

X-ray diffraction
2.1Å resolution

Crystal structure of chicken VE-cadherin EC1-2

Released:
DOI: 10.2210/pdb3ppe/pdb
PDB entry 3ppe coloured by chain, front view.
PDB entry 3ppe coloured by chain, side view.
PDB entry 3ppe coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Structure and binding mechanism of vascular endothelial cadherin: a divergent classical cadherin.
Brasch J, Harrison OJ, Ahlsen G, Carnally SM, Henderson RM, Honig B, Shapiro L
J Mol Biol 408 57-73 (2011)
PMID: 21269602

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183828 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 203 amino acids
Theoretical weight: 22.69 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8AYD0 (Residues: 41-243; Coverage: 27%)
Gene name: CDH5
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

1 bound ligand:
Ligand CA 6 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P43212
Unit cell:
a: 99.973Å b: 99.973Å c: 105.987Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.184 0.242
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Protein Interactions at Endothelial Junctions and Signaling Mechanisms Regulating Endothelial Permeability.
Komarova et al. (2017)
10 more

8 mentions without citation

Thinking outside the cell: how cadherins drive adhesion.
Brasch et al. (2012)
7 more