› 3q02

X-ray diffraction
2.3Å resolution

Crystal structure of plasminogen activator inhibitor-1 in a metastable active conformation.

Released:
DOI: 10.2210/pdb3q02/pdb
PDB entry 3q02 coloured by chain, front view.
PDB entry 3q02 coloured by chain, side view.
PDB entry 3q02 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of plasminogen activator inhibitor-1 in an active conformation with normal thermodynamic stability.
Jensen JK, Thompson LC, Bucci JC, Nissen P, Gettins PG, Peterson CB, Andreasen PA, Morth JP
J Biol Chem 286 29709-17 (2011)
PMID: 21697084

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-138523 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasminogen activator inhibitor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 379 amino acids
Theoretical weight: 42.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05121 (Residues: 24-402; Coverage: 100%)
Gene names: PAI1, PLANH1, SERPINE1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand CL 2 x CL
Ligand ZN 2 x ZN
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 77.438Å b: 67.172Å c: 90.357Å
α: 90° β: 98.5° γ: 90°
R-values:
R R work R free
0.195 0.193 0.238
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

A Narrative Review on Plasminogen Activator Inhibitor-1 and Its (Patho)Physiological Role: To Target or Not to Target?
Sillen et al. (2021)
1 more

13 mentions without citation

TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections.
Shen et al. (2017)
12 more