› 3q0h

X-ray diffraction
1.7Å resolution

Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT)

Released:
DOI: 10.2210/pdb3q0h/pdb
PDB entry 3q0h coloured by chain, front view.
PDB entry 3q0h coloured by chain, side view.
PDB entry 3q0h coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ramagopal UA, Guo H, Samanta D, Nathenson SG, Almo SC, New York Structural Genomics Research Consortium (NYSGRC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175398 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
T-cell immunoreceptor with Ig and ITIM domains Chains: A, B
Molecule details ›
Chains: A, B
Length: 117 amino acids
Theoretical weight: 12.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q495A1 (Residues: 22-137; Coverage: 52%)
Gene names: TIGIT, VSIG9, VSTM3
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21
Unit cell:
a: 39.951Å b: 74.671Å c: 43.346Å
α: 90° β: 92.39° γ: 90°
R-values:
R R work R free
0.209 0.207 0.237
Expression system: Escherichia coli BL21(DE3)

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