› 3q2w

X-ray diffraction
3.2Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147223 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Cadherin-2 Chain: A
Molecule details ›
Chain: A
Length: 559 amino acids
Theoretical weight: 61.53 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P15116 (Residues: 160-712; Coverage: 63%)
Gene name: Cdh2
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand CA 12 x CA
Ligand MAN 9 x MAN
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: C2221
Unit cell:
a: 91.372Å b: 111.648Å c: 262.107Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.23 0.267
Expression system: Homo sapiens

Quick links

Citations

58 review citations

The extracellular matrix in tumor progression and metastasis.
Eble et al. (2019)
57 more

22 mentions without citation

Thinking outside the cell: how cadherins drive adhesion.
Brasch et al. (2012)
21 more