› 3q37

X-ray diffraction
1.65Å resolution

Identification of Amino Acids that Account for Long-Range Interactions in Proteins Using Two Triosephosphate Isomerases from Pathogenic Trypanosomes.

Released:
DOI: 10.2210/pdb3q37/pdb
PDB entry 3q37 coloured by chain, front view.
PDB entry 3q37 coloured by chain, side view.
PDB entry 3q37 coloured by chain, top view.
Source organisms:
Primary publication:
Identification of amino acids that account for long-range interactions in two triosephosphate isomerases from pathogenic trypanosomes.
García-Torres I, Cabrera N, Torres-Larios A, Rodríguez-Bolaños M, Díaz-Mazariegos S, Gómez-Puyou A, Perez-Montfort R
PLoS One 6 e18791 (2011)
PMID: 21533154

Function and Biology Details

Reaction catalysed: 
D-glyceraldehyde 3-phosphate = glycerone phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138174 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Triosephosphate isomerase, glycosomal Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 251 amino acids
Theoretical weight: 27.32 KDa
Source organisms: Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04789 (Residues: 2-42, 100-121; Coverage: 25%)
  • Canonical: P52270 (Residues: 44-100, 123-251; Coverage: 74%)
Sequence domains: Triosephosphate isomerase
Structure domains: Aldolase class I

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 83.594Å b: 77.258Å c: 85.387Å
α: 90° β: 116.6° γ: 90°
R-values:
R R work R free
0.19 0.189 0.22
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

A guide to the effects of a large portion of the residues of triosephosphate isomerase on catalysis, stability, druggability, and human disease.
Olivares-Illana et al. (2017)
9 other articles

5 mentions without citation

The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking Investigations.
Ogungbe et al. (2016)
4 more