› 3q3g

X-ray diffraction
2.7Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210501 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Antibody Light Chain Chains: A, C, F, J
Molecule details ›
Chains: A, C, F, J
Length: 220 amino acids
Theoretical weight: 24.46 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Antibody Heavy chain Chains: B, D, H, K
Molecule details ›
Chains: B, D, H, K
Length: 224 amino acids
Theoretical weight: 24.04 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Integrin alpha-M Chains: E, G, I, L
Molecule details ›
Chains: E, G, I, L
Length: 190 amino acids
Theoretical weight: 21.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11215 (Residues: 148-337; Coverage: 17%)
Gene names: CD11B, CR3A, ITGAM
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

6 bound ligands:
Ligand EDO 25 x EDO
Ligand GOL 11 x GOL
Ligand NA 3 x NA
Ligand CA 4 x CA
Ligand CL 5 x CL
Ligand PEG 1 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 81.939Å b: 157.218Å c: 232.128Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.211 0.244
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Integrins as Therapeutic Targets: Successes and Cancers.
Raab-Westphal et al. (2017)
6 more

6 mentions without citation

Blind prediction performance of RosettaAntibody 3.0: grafting, relaxation, kinematic loop modeling, and full CDR optimization.
Weitzner et al. (2014)
5 more