› 3q5j

X-ray diffraction
2.1Å resolution

Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LMJF33.0312:M1-K213 in the presence of 17-DMAP-geldanamycin

Released:
DOI: 10.2210/pdb3q5j/pdb
PDB entry 3q5j coloured by chain, front view.
PDB entry 3q5j coloured by chain, side view.
PDB entry 3q5j coloured by chain, top view.
Source organism: Leishmania major
Entry authors: Wernimont AK, Tempel W, Lin YH, Hutchinson A, MacKenzie F, Fairlamb A, Cossar D, Zhao Y, Schapira M, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Ferguson MAJ, Hui R, Pizarro JC, Hills T, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175674 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histidine kinase/HSP90-like ATPase domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 231 amino acids
Theoretical weight: 26.11 KDa
Source organism: Leishmania major
Expression system: Escherichia coli
UniProt:
  • Canonical: Q4Q4I6 (Residues: 1-213; Coverage: 30%)
Gene names: HSP83, HSP83-10, HSP83-11, HSP83-12, HSP83-13, HSP83-14, HSP83-15, HSP83-16, HSP83-17, HSP83-2, HSP83-3, HSP83-5, HSP83-6, HSP83-7, HSP83-9, LMJF_33_0312, LMJF_33_0314, LMJF_33_0316, LMJF_33_0320, LMJF_33_0323, LMJF_33_0326, LMJF_33_0333, LMJF_33_0336, LMJF_33_0340, LMJF_33_0343, LMJF_33_0346, LMJF_33_0350, LMJF_33_0355, LMJF_33_0360, LMJF_33_0365
Sequence domains: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Structure domains: Histidine kinase-like ATPase, C-terminal domain

Ligands and Environments

1 bound ligand:
Ligand D1S 1 x D1S
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: I41
Unit cell:
a: 111.73Å b: 111.73Å c: 48.98Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.202 0.234
Expression system: Escherichia coli

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