› 3q6i

X-ray diffraction
2.59Å resolution

Crystal structure of FabG4 and coenzyme binary complex

Released:
DOI: 10.2210/pdb3q6i/pdb
PDB entry 3q6i coloured by chain, front view.
PDB entry 3q6i coloured by chain, side view.
PDB entry 3q6i coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Entry authors: Dutta D, Bhattacharyya S, Das AK

Function and Biology Details

Reaction catalysed: 
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129464 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3-oxoacyl-(Acyl-carrier-protein) reductase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 446 amino acids
Theoretical weight: 46.1 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: O53665 (Residues: 17-454; Coverage: 97%)
Gene names: MT0256, fabG-1
Sequence domains: Enoyl-(Acyl carrier protein) reductase
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments


Cofactor: Ligand NAD 4 x NAD
1 bound ligand:
Ligand ZPG 1 x ZPG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P1
Unit cell:
a: 63.069Å b: 71.027Å c: 92.917Å
α: 105.02° β: 97.06° γ: 93.66°
R-values:
R R work R free
0.171 0.168 0.242
Expression system: Escherichia coli

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