› 3q7g

X-ray diffraction
2.3Å resolution

Crystal Structure of E2 domain of Human Amyloid Precursor-Like Protein 1 in complex with SOS (sucrose octasulfate)

Released:
DOI: 10.2210/pdb3q7g/pdb
PDB entry 3q7g coloured by chain, front view.
PDB entry 3q7g coloured by chain, side view.
PDB entry 3q7g coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the E2 domain of amyloid precursor protein-like protein 1 in complex with sucrose octasulfate.
Xue Y, Lee S, Wang Y, Ha Y
J Biol Chem 286 29748-57 (2011)
PMID: 21715329

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156407 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Amyloid beta precursor like protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 214 amino acids
Theoretical weight: 24.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51693 (Residues: 285-494; Coverage: 34%)
Gene name: APLP1
Sequence domains: E2 domain of amyloid precursor protein
Structure domains: Amyloid precursor protein, E2 domain

Ligands and Environments

Carbohydrate polymer : NEW Components: GU4, YYJ
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P212121
Unit cell:
a: 73.548Å b: 82.236Å c: 89.923Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.217 0.261
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Demystifying heparan sulfate-protein interactions.
Xu et al. (2014)
3 more

2 mentions without citation

Crystal structure of the E2 domain of amyloid precursor protein-like protein 1 in complex with sucrose octasulfate.
Xue et al. (2011)
1 more