› 3q8w

X-ray diffraction
3.64Å resolution

A b-aminoacyl containing thiazolidine derivative and DPPIV complex

Released:
DOI: 10.2210/pdb3q8w/pdb
PDB entry 3q8w coloured by chain, front view.
PDB entry 3q8w coloured by chain, side view.
PDB entry 3q8w coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Lee JO, Song DH

Function and Biology Details

Reaction catalysed: 
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151015 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dipeptidyl peptidase 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 732 amino acids
Theoretical weight: 85.08 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P27487 (Residues: 39-764; Coverage: 95%)
Gene names: ADCP2, CD26, DPP4
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand AZV 2 x AZV
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: P212121
Unit cell:
a: 118.412Å b: 124.501Å c: 133.119Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.282 0.282 0.324
Expression system: Trichoplusia ni

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