› 3qa8

X-ray diffraction
3.6Å resolution

Crystal Structure of inhibitor of kappa B kinase beta

Released:
DOI: 10.2210/pdb3qa8/pdb
PDB entry 3qa8 coloured by chain, front view.
PDB entry 3qa8 coloured by chain, side view.
PDB entry 3qa8 coloured by chain, top view.
Source organism: Xenopus laevis
Primary publication:
Crystal structure of inhibitor of κB kinase β.
Xu G, Lo YC, Li Q, Napolitano G, Wu X, Jiang X, Dreano M, Karin M, Wu H
Nature 472 325-30 (2011)
PMID: 21423167

Function and Biology Details

Reaction catalysed: 
ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein]
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179764 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
IkappaB kinase Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 676 amino acids
Theoretical weight: 77.87 KDa
Source organism: Xenopus laevis
UniProt:
  • Canonical: Q6INT1 (Residues: 1-659; Coverage: 89%)
Gene names: MGC80376, ikbkb, ikbkb.L, ikk-beta, ikk2, ikkb, ikkbeta
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P1
Unit cell:
a: 103.17Å b: 140.339Å c: 161.167Å
α: 71.28° β: 79.56° γ: 86.04°
R-values:
R R work R free
0.31 0.308 0.344

Quick links

Citations

22 review citations

NF-κB, the first quarter-century: remarkable progress and outstanding questions.
Hayden et al. (2012)
21 more

14 mentions without citation

NF-κB regulation: lessons from structures.
Ghosh et al. (2012)
13 more