› 3qae

X-ray diffraction
2.3Å resolution

3-hydroxy-3-methylglutaryl-coenzyme A reductase of Streptococcus pneumoniae

Released:
DOI: 10.2210/pdb3qae/pdb
PDB entry 3qae coloured by chain, front view.
PDB entry 3qae coloured by chain, side view.
PDB entry 3qae coloured by chain, top view.
Source organism: Streptococcus pneumoniae R6
Entry authors: Zhang L, Feng L, Zhou L, Gui J, Wan J

Function and Biology Details

Reaction catalysed: 
(R)-mevalonate + CoA + 2 NAD(+) = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184118 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3-hydroxy-3-methylglutaryl coenzyme A reductase Chain: A
Molecule details ›
Chain: A
Length: 458 amino acids
Theoretical weight: 49.85 KDa
Source organism: Streptococcus pneumoniae R6
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8DNS5 (Residues: 1-424; Coverage: 100%)
Gene names: mvaA, spr1570
Sequence domains: Hydroxymethylglutaryl-coenzyme A reductase
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand CIT 1 x CIT
Ligand GOL 1 x GOL
Ligand NA 27 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: OXFORD DIFFRACTION ENHANCE ULTRA
Spacegroup: C2221
Unit cell:
a: 73.483Å b: 90.367Å c: 160.621Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.207 0.241
Expression system: Escherichia coli

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